Thermo Fisher Scientific SNAIL Monoclonal Antibody (C.775.8)
SNAIL 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간, 생쥐, 랫드 시료에서 Western blot에 사용 가능. Affinity chromatography로 정제된 액상 항체이며, E-cadherin 발현 억제 및 EMT 연구에 적합. -20°C에서 보관.
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.775.8 |
| Immunogen | Recombinant human Snail protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10985548 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and functions in mesoderm and neural crest formation.
SNAI1 is an important factor in tumor invasion through E-cadherin downregulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, expression of SNAI1 and/or SNAI2 (Slug) is associated with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis.
Snail 1 protein in the stroma may serve as a potential prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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