Thermo Fisher Scientific Phospho-RyR2 (Ser2814) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of RYR2 only when phosphorylated at Ser2814.

Target Information

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca²⁺ from internal stores.
The alpha1-subunit of the DHPR contains a cytoplasmic loop involved in interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles.
Cells lacking RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca²⁺ current density.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.