Thermo Fisher Scientific TRIB1 Monoclonal Antibody (OTI1B11), TrueMAB
인간 TRIB1 단백질을 인식하는 마우스 단클론 항체로, Western blot에 적합합니다. TrueMAB 포맷으로 제공되며, 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 PBS/BSA/glycerol 버퍼에 보존되며, -20°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific TRIB1 Monoclonal Antibody (OTI1B11), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B11 |
| Immunogen | Full length human recombinant protein of human TRIB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TRIB1, also known as gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activity.
Overexpression of TRIB1 in HeLa cells represses IL8 promoter basal activity by inhibiting AP1 activity. It also inhibits oncogenic Ras-driven and MEKK1-mediated AP1 activation, while enhancing ERK activation.
Coimmunoprecipitation and yeast 2-hybrid assays show that MEK1 interacts with TRIB1 and TRIB3, and MKK4 interacts specifically with TRIB1. Cotransfection of MKK4 enhances TRIB1 levels, indicating that TRIB-MAPKK interaction stabilizes TRIB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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