Thermo Fisher Scientific HIP55 Polyclonal Antibody
HIP55 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 적합하며 인간, 개, 쥐에서 반응 예상. 합성 펩타이드 면역원 사용, 액상 형태로 제공. -20°C에서 보관, 연구용 전용.
- 카탈로그번호
- PA518046
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.03–0.1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (AANLSRNGPALQE) corresponding to the N-terminus amino acids of DBNL (aa 2–15) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977701 |
Product Specific Information
- Recognizes all reported isoforms (NP_054782.2; NP_001014436.1; NP_001116428.1).
- Predicted to react with canine and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance (MCM) proteins essential for the initiation of eukaryotic genome replication.
The MCM complex (including MCM2, 6, and 7) functions as a DNA helicase and plays a key role in the pre-replication complex (pre_RC), contributing to replication fork formation and recruitment of DNA replication-related proteins.
Phosphorylation by CDC2 kinase reduces the helicase activity and chromatin binding of the MCM complex.
This gene is located near PRKDC/DNA-PK on chromosome 8, a region associated with DNA double-strand break repair.
Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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