Thermo Fisher Scientific Human FAIM3 Synthetic Peptide
인간 FAIM3 단백질의 13개 아미노산 서열 기반 합성 펩타이드로, 항체 차단 실험에 사용 가능. 순도 높은 액상 형태로 제공되며 PBS(pH 7.2) 버퍼에 0.1% BSA와 0.02% sodium azide 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PEP0403
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human FAIM3 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human Toso.
PEP-0403 can be used as a blocking peptide with polyclonal antibody PA5-20285.
Target Information
Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)-containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7.
Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice renders these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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