Thermo Fisher Scientific Human AVEN Synthetic Peptide
인간 Aven 단백질의 N-말단 14개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20288의 블로킹 펩타이드로 사용 가능. 세포사멸(apoptosis) 연구 및 단백질 상호작용 분석에 적합. 연구용으로만 사용.
- 카테고리
- Protein
- 판매단위
- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the amino terminus of human Aven.
PEP-0406 can be used as a blocking peptide with polyclonal antibody PA5-20288.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer.
Aven is a protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought to function by binding to Bcl-xL (an antiapoptotic member of the Bcl-2 family) and Apaf-1, possibly interfering with Apaf-1 self-association. This suggests that Aven impedes Apaf-1-mediated caspase activation.
Higher levels of Aven mRNA are observed in patients with acute leukemia compared to controls, suggesting that Aven may serve as a prognostic indicator in leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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