Thermo Fisher Scientific MTDH Monoclonal Antibody (OTI1E7), TrueMAB
MTDH 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. Human 시료 반응성. Affinity chromatography로 정제된 액상 포맷. Metadherin 연구용으로 적합하며, -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 70–582 of human MTDH produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC (Lysine-Rich CEACAM1 co-isolated), is a novel protein localized with tight junction proteins ZO-1 and occludin in polarized epithelial cells.
It is not a structural component but is recruited during tight junction maturation. Metadherin is overexpressed in breast cancer tissues and xenografts, with lower expression in normal breast tissue.
It binds to lung vasculature, a common site of breast cancer metastasis, via a C-terminal extracellular domain segment. Blocking this domain with antibodies or siRNA can inhibit breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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