Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI6A9), TrueMAB
Periostin 단백질 검출용 Mouse Monoclonal Antibody (OTI6A9). Western blot에 최적화된 TrueMAB 형식. Human 시료에 반응하며, 고순도의 Affinity chromatography 정제. 안정적인 PBS/BSA buffer에 보관, 연구용 전용 시약.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 538–781 of human POSTN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment. It is mainly detected in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1). The protein contains a signal sequence, a cysteine-rich domain, a fourfold repeated domain homologous to insect fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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