Thermo Fisher Scientific PKD1 Polyclonal Antibody
Rabbit polyclonal antibody against human PKD1 for WB and IHC applications. Lyophilized form, reconstitute with distilled water. Ideal for studying renal tubulogenesis and cilium mechanosensation. For research use only.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human PKD1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2165461 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
Target Information
PKD1 is involved in renal tubulogenesis and fluid-flow mechanosensation by the primary cilium in renal epithelium. It acts as a regulator of cilium length together with PKD2. The dynamic control of cilium length is essential for mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium decreases intracellular cAMP, leading to cilium shortening and reduced flow-induced signaling. PKD1 may also function as an ion-channel regulator and participate in adhesive protein-protein and protein-carbohydrate interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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