Thermo Fisher Scientific HAVCR1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:1,000 dilution

Product Specifications

Product Specific Information

Protein sequence:
MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPMTT VPTTTVPTTM SIPTTTTVLT TMTVSTTTSV PTTTSIPTTT SVPVTTTVST FVPPMPLPRQ NHEPVATSPS SPQPAETHPT TLQGAIRREP TSSPLYSYTT DGNDTVTESS DGLWNNNQTQ LFLEHSLLTA NTTKGIYAGV CISVLVLLAL LGVIIAKKYF FKKEVQQLSV SFSSLQIKAL QNAVEKEVQA EDNIYIENSL YATD

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
CD365 binds to Tim-4 and serves as a receptor or co-receptor for several viruses such as hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Polymorphisms in the HAVCR1 gene are linked to infection susceptibility and disease severity.
CD365 is primarily expressed in epithelial cells and in cell lines such as A549, 769-P, and Caco-2.
A soluble form is produced via metalloproteinase-mediated proteolytic cleavage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.