Thermo Fisher Scientific Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)
Tau 단백질의 Thr231 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, IP 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트에 반응하며 Protein A로 정제된 액상 형태. 알츠하이머병 연구 등 신경퇴행성 질환 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:800 | - |
| Immunohistochemistry (Frozen) (IHC-F) | 1:50–1:800 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC58-08 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Thr231 of human Tau-F |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931481 |
Target Information
Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1, or TAU, is a 758 amino acid protein localized in the cytoplasm, cytoskeleton, and cell membrane. It contains four Tau/MAP repeats and is expressed in neuronal tissue as multiple alternatively spliced isoforms. Tau promotes microtubule assembly and stability, maintaining neuronal polarity and linking microtubules with neural plasma membrane components. It undergoes various post-translational modifications, including phosphorylation, polyubiquitination, and glycation. Mutations in the Tau gene are associated with Alzheimer’s disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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