Thermo Fisher Scientific RAPGEF5 Polyclonal Antibody
RAPGEF5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot에 적합하며, 인간 시료에 반응. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing amino acids 1–179 of Human RAPGEF5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.74 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153910 |
Product Specific Information
- Recommended positive controls: H1299, HeLaS3
- Predicted reactivity: Mouse (86%), Rhesus Monkey (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches cycling between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac (Rap guanine nucleotide exchange factor 5, RAPGEF5), serve as RAS activators by promoting GTP acquisition to maintain the active state. RAPGEF5 is a 580 amino acid protein expressed mainly in brain and testis, with weaker expression in heart, placenta, lung, pancreas, and small intestine. It exists in two alternatively spliced isoforms and is conserved in cow, mouse, and rat. The human Repac gene maps to chromosome 7p15.3, a region associated with positive response to erlotinib therapy in non-small-cell lung cancer.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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