Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody
PLCG2 단백질의 Tyr1217 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 응용에 적합. 1 mg/mL 농도의 액상 형태로 제공되며, PBS 및 50% glycerol buffer에 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PLCG2 (Accession P16885), corresponding to amino acid residues around phosphorylated Tyr1217 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816160 |
Product Specific Information
This antibody detects endogenous levels of PLCG2 only when phosphorylated at Tyr1217.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are various mammalian PLC isozymes, including PLC beta1–4, PLC gamma1–2, PLC delta1–2, and PLC epsilon.
PLC delta1 acts as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It functions as an effector for transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling.
Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLC delta in Alzheimer’s disease brains suggests its potential role in AD pathology.
PLC delta2 expression is associated with intestinal metaplasia and adenocarcinoma, and may serve as a marker for gastric malignant transformation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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