Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (MRC OX-26)
Transferrin receptor(CD71)을 인식하는 MRC OX-26 클론의 mouse monoclonal antibody. Western blot 및 유세포분석(Flow cytometry)에 적합. Rat 및 mouse 시료 반응. 1 mg/mL 농도의 액상 형태로 제공되며, PBS buffer에 보존제 미첨가 상태. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 10 µL for 10⁶ cells in 100 µL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MRC OX-26 |
| Immunogen | PHA activated rat lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | IgG fraction |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2201365 |
Product Specific Information
MA1-90784 detects CD71 from rat samples.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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