Thermo Fisher Scientific CD45 Monoclonal Antibody (MRC OX-1), PE
CD45 단백질을 인식하는 마우스 모노클론 항체로, Rat 시료에 반응합니다. PE 형광체가 결합되어 Flow Cytometry 및 IHC(F) 분석에 적합합니다. 단백질 G 정제, PBS/BSA 버퍼에 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD45 Monoclonal Antibody (MRC OX-1), PE
Applications
- Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MRC OX-1 |
| Immunogen | Partially purified rat thymocyte membrane glycoproteins |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles; store in the dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955313 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent on non-hematopoietic cell lines and tissues, both normal and malignant. CD45 plays a critical role in lymphocyte development and antigen signaling, functioning as a regulator of Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains. CD45 isoforms exhibit cell-type and physiological state-dependent expression and are key regulators of T- and B-cell receptor signaling, cytokine receptor pathways, and integrin-mediated signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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