Thermo Fisher Scientific B7-2 (CD86) Monoclonal Antibody (OTI11E3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation.
In the absence of sufficient CD86/CD80 co-stimulation, antigen presentation can induce tolerance. CD86 is a type I membrane protein and a member of the immunoglobulin superfamily, expressed on antigen-presenting cells.
It binds to CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells, providing either activation or inhibitory signals.
Alternative splicing results in multiple transcript variants encoding different isoforms.
CD86 dysfunction has been associated with gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.