Thermo Fisher Scientific STIM2 Polyclonal Antibody
STIM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. Human 반응성, 1 mg/mL 농도, PBS/glycerol/BSA buffer 구성. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human STIM2 (aa 1–140) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854740 |
Product Specific Information
- Positive Control: 293T, AGS, HeLa, human kidney tissue, human placenta tissue, mouse testis tissue.
Target Information
In T lymphocytes, Ca²⁺ entry following antigen-receptor binding occurs through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels composed of ORAI1 and STIM1. STIM1 acts as a Ca²⁺ sensor and activates CRAC channels by migrating to the plasma membrane from ER-like Ca²⁺ stores. A related molecule, STIM2, inhibits STIM1-mediated Ca²⁺ entry and can form complexes with STIM1, suggesting a coordinated role in regulating Ca²⁺ influx. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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