Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (SPM523)

Applications and Tested Dilutions

Product Specifications

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode two extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA lacks polymorphisms in the peptide-binding region and serves as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains the polymorphisms that determine peptide-binding specificity. Numerous DRB1 alleles have been identified, and typing for these polymorphisms is routinely used in bone marrow and kidney transplantation. HLA-DR is primarily expressed on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The human MHC class II region includes DR, DQ, and DP loci, which encode the major expressed products. These molecules bind intracellularly processed peptides, present them to T-helper cells, and play a crucial role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.