Thermo Fisher Scientific CD74 (B-Cell Marker) (Transcription Regulator) Monoclonal Antibody (CLIP/7946)
CD74 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체로, 사람 시료에 반응하며 IHC(P), IHC(PFA) 실험에 적합합니다. 단클론 CLIP/7946, Mouse IgG kappa 형식으로 제작되었으며, 단백질 A/G 정제 및 PBS(pH 7.4) 용액에 보관됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLIP/7946 |
| Immunogen | Recombinant fragment of human CD74 protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with DRB1 containing polymorphisms determining peptide-binding specificity.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
MHC class II molecules bind processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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