Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Does not react with Rat

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains 5 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the two extracellular domains
• Exon 4 encodes the transmembrane domain and the cytoplasmic tail

DRA lacks polymorphisms in the peptide-binding region and serves as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
The beta chain contains all polymorphisms determining peptide-binding specificity. Hundreds of DRB1 alleles have been described, and typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation.

HLA-DR is primarily expressed on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.