Thermo Fisher Scientific S1P1 Polyclonal Antibody
S1P1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. 인간, 생쥐, 랫드 반응성. 고순도 항원 친화 크로마토그래피 정제. -20°C 보관, PBS/BSA 버퍼 포함.
- 카탈로그번호
- PA11040
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | View 8 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | – | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues S(359) H P Q K D D G D N P E T I(372) of mouse S1P1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2184729 |
Product Specific Information
PA1-1040 detects S1P1 protein in transfected human and mouse cell samples with no cross-reactivity to S1P3.
It is validated for immunofluorescence, immunohistochemistry, immunoprecipitation, and Western blot applications.
By Western blot, it detects an ~44 kDa recombinant S1P1 protein from transfected HEK293 cells.
Immunofluorescence data shows S1P1 localization to the plasma membrane after staining with PA1-1040.
The immunogen peptide (Cat. # PEP-220) is conserved across species and available for neutralization and control experiments.
Target Information
S1P1 is a G-protein coupled receptor for sphingosine 1-phosphate (S1P), linked to G(i) proteins.
Its signaling activates RAC1, SRC, PTK2/FAK1, and MAP kinases, regulating actin cytoskeleton reorganization and lamellipodia formation.
S1P1 is essential for normal chemotaxis toward S1P, embryonic heart development, and cardiac morphogenesis.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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