Thermo Fisher Scientific TAP2 Polyclonal Antibody
Human TAP2 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC(P)에서 1:1,000~1:2,500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성 제공. 장기 보관 시 -20°C에서 안정적 유지. 연구용으로만 사용.
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Thermo Fisher Scientific TAP2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TAP2. Recombinant protein control fragment (Product #RP-95379). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648214 |
Product Specific Information
Immunogen sequence:
GSGKSTVAAL LQNLYQPTGG QVLLDEKPIS QYEHCYLHSQ VVSVGQEPVL FSGSVRNNIA YGLQSCEDDK VMAAAQAAHA DDFIQEMEHG IYTDVGEKGS QLAAGQKQRL AIARALVRDP RVLILDEATS ALDVQCEQA
Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 81%
Target Information
The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, involved in multidrug resistance and antigen presentation. The gene is located 7 kb telomeric to ABCB2 and forms a heterodimer with ABCB2 to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
Alternative splicing produces two isoforms differing in peptide selectivity and MHC class I surface expression restoration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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