Thermo Fisher Scientific IDO2/Indoleamine 2,3-dioxygenase 2 Monoclonal Antibody (IDO2/2638)
IDO2 단백질을 인식하는 Mouse monoclonal 항체. IHC(P), ELISA, Peptide Array 등 다양한 응용에 적합. Human 시료에 반응하며, 단백질 A/G로 정제된 액상 형태. 4°C 보관, 24개월 안정성 보장.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IDO2/2638 |
| Immunogen | Recombinant fragment (around aa 200–350) of human IDO2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human placenta or liver.
- Cellular Localization: Cytoplasm
Specificity Comments:
IDO2 is a presumptive immunomodulatory gene based on its structural similarity to IDO1 and expression in various antigen-presenting cells. Both IDO1 and IDO2 catalyze the conversion of tryptophan to kynurenine. Although both enzymes exhibit robust catabolic activity, IDO2 requires slightly different in vitro conditions to reach the same activity level as IDO1. The enzymatic activity of IDO2 in human dendritic cells remains under debate. Further research is needed to clarify substrate preferences and reaction pathways. Distinct expression patterns and responses to stimuli suggest non-redundant functions between IDO1 and IDO2.
Target Information
Along with enzymes encoded by the INDO and TDO2 genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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