Thermo Fisher Scientific IDO2/Indoleamine 2,3-dioxygenase 2 Monoclonal Antibody (IDO2/2638)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

ELISA (ELISA)

Assay-dependent

-

Peptide Array (Array)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG, kappa

Class

Monoclonal

Type

Antibody

Clone

IDO2/2638

Immunogen

Recombinant fragment (around aa 200-350) of human IDO2 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IDO2,uniProtId:Q6ZQW0-1,ncbiNodeId:9606,antigenRange:200-350,antigenLength:420,antigenImageFileName:169355-MSM1-P1_IDO2_Q6ZQW0-1_House_mouse.svg,antigenImageFileNamePDP:169355-MSM1-P1_IDO2_Q6ZQW0-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Antibody is stable for 24 months.

Positive Control: Human placenta or liver. Cellular Localization: Cytoplasm

Specificity Comments: IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

Target Information

Along with the enzymes encoded by the INDO and TDO2 genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.