Thermo Fisher Scientific AGR2 Monoclonal Antibody (OTI5E10), TrueMAB
AGR2 단백질을 인식하는 mouse monoclonal antibody로 Western blot 및 IHC에 적합. Human, Mouse, Rat 반응성. Lyophilized 형태이며 PBS 기반 버퍼에 trehalose 포함. 암 관련 연구 및 표지자 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E10 |
| Immunogen | Human recombinant protein fragment (aa 21–175 of human AGR2) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.3) with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL antibody concentration.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
AGR2 (anterior gradient protein 2) and AGR3 belong to the anterior gradient homolog family.
They are secreted cytoplasmic proteins involved in metastasis induction and inhibition of the p53 tumor suppressor.
AGR2 may serve as a molecular marker and potential therapeutic target for hormone-responsive breast tumors.
It is ubiquitously expressed and upregulated in prostate, breast, lung, renal, and endometrial carcinomas.
AGR2 expression correlates positively with estrogen receptor (ER) and negatively with epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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