Thermo Fisher Scientific LIN7B Monoclonal Antibody (OTI1G2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

LIN7B plays a role in establishing and maintaining asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
It forms membrane-associated multiprotein complexes that regulate delivery and recycling of proteins to correct membrane domains.
LIN7 (LIN7A, LIN7B, or LIN7C) forms a tripartite complex with CASK and APBA1, potentially coupling synaptic vesicle exocytosis to cell adhesion in the brain.
Ensures proper localization of GRIN2B (NMDA receptor subunit 2B) to postsynaptic density and localizes synaptic vesicles at synapses via β-catenin and cadherin.
Required for localization of Kir2 channels, GABA transporter (SLC6A12), and EGFR/ERBB family receptors to the basolateral membrane of epithelial cells.
May enhance ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.