Thermo Fisher Scientific GEMC1 Polyclonal Antibody
GEMC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 생쥐 시료에 반응하며 Western blot에 적합. 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 2–8°C에서 보관 가능.
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Thermo Fisher Scientific GEMC1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1 µg/mL
Publications: –
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the center of human GEMC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152502 |
Product Specific Information
- Suggested positive control: mouse heart tissue lysate
- PA5-21158 can be used with blocking peptide PEP-1272
Target Information
Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein required for chromosomal replication.
GEMC1 contains a region similar to the coiled-coil domain of geminin, essential for vertebrate DNA replication.
It binds to checkpoint and replication factor TopBP1, allowing chromatin association during pre-replication complex formation.
GEMC1 also interacts with replication factors Cdc45 and Cdk2-CyclinE, stimulating initiation of DNA replication.
siRNA-mediated depletion of GEMC1 impairs Cdc45 loading onto chromatin, indicating its role in TopBP1 and Cdk2-dependent recruitment of Cdc45 to replication origins.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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