Thermo Fisher Scientific IFT57 Monoclonal Antibody (OTI4F6), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

HIPPI (IFT57) is required for the formation of cilia and plays an indirect role in sonic hedgehog signaling, as cilia are necessary for hedgehog pathway activity.
It also exhibits pro-apoptotic function via interaction with HIP1, leading to recruitment of caspase-8 (CASP8) and induction of apoptosis.
HIPPI can bind to the DNA sequence motif 5'-AAAGACATG-3' in the promoters of caspase genes such as CASP1, CASP8, and CASP10, suggesting a potential transcription regulatory role, though its relevance remains unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.