Thermo Fisher Scientific IFT57 Monoclonal Antibody (OTI4F6), TrueMAB
IFT57 단백질을 인식하는 Mouse monoclonal antibody로, Human 시료에 반응합니다. Western blot, IHC(P), ICC/IF에 사용 가능하며, 고순도의 Affinity chromatography 정제 제품입니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F6 |
| Immunogen | Full length human recombinant protein of human IFT57 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
HIPPI (IFT57) is required for the formation of cilia and plays an indirect role in sonic hedgehog signaling, as cilia are necessary for hedgehog pathway activity.
It also exhibits pro-apoptotic function via interaction with HIP1, leading to recruitment of caspase-8 (CASP8) and induction of apoptosis.
HIPPI can bind to the DNA sequence motif 5'-AAAGACATG-3' in the promoters of caspase genes such as CASP1, CASP8, and CASP10, suggesting a potential transcription regulatory role, though its relevance remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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