Thermo Fisher Scientific GSTM2 Recombinant Rabbit Monoclonal Antibody (011)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody has specificity for Human GSTM2.

Target Information

Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
GSTM2 belongs to the mu class and functions in detoxification of electrophilic compounds such as carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products by conjugation with glutathione.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. The genes encoding the mu class of enzymes are organized in a cluster on chromosome 1p13.3 and are highly polymorphic. These genetic variations can influence susceptibility to carcinogens and toxins, as well as drug toxicity and efficacy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.