Thermo Fisher Scientific GABRA1 Polyclonal Antibody
GABRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간과 설치류에 반응하며 고순도 항원 친화 크로마토그래피로 정제되었습니다. 신경전달 관련 연구용으로 추천됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–261 of Human GABA A Receptor alpha 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545461 |
Product Specific Information
- Recommended positive controls: U87-MG, SK-N-SH
- Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (89%), Rabbit (100%), Chicken (98%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through opening of a Cl⁻ channel associated with the GABAA receptor (GABAA-R) subtype.
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex composed of multiple alpha, beta, and gamma subunits, including splice variants. Expression of alpha and beta subunits yields functional GABAA-R sensitive to GABA, while gamma subunit coexpression is required for benzodiazepine modulation.
Phosphorylation of beta subunits modulates receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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