Thermo Fisher Scientific FBXO32 Polyclonal Antibody
FBXO32 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 근육 위축 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FBXO32 (Accession Q969P5), corresponding to amino acid residues N50–L100. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854581 |
Product Specific Information
Antibody detects endogenous levels of total FBXO32.
Target Information
The FBXO32 gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif. F-box proteins are subunits of the ubiquitin protein ligase complex (SCF), which functions in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:
- Fbws: containing WD-40 domains
- Fbls: containing leucine-rich repeats
- Fbxs: containing various protein-protein interaction modules or no recognizable motifs
FBXO32 belongs to the Fbxs class and contains an F-box domain. It is highly expressed during muscle atrophy, and mice deficient in this gene are resistant to atrophy. Therefore, FBXO32 is a potential drug target for the treatment of muscle atrophy.
Alternative splicing results in two transcript variants encoding isoforms of different sizes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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