Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser8) Polyclonal Antibody
Phospho-Ser8 Tyrosine Hydroxylase 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 적용 가능. 1 mg/mL 액상 형태, -20°C 보관. 도파민 및 카테콜아민 합성 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser8 (A-P-SP-P-Q) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554945 |
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains.
TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology. Its role in neurotransmitter synthesis is linked to neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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