Thermo Fisher Scientific Human alpha-1 PDX Recombinant Protein
인간 유래 alpha-1 PDX 재조합 단백질로, furin 억제 연구에 사용됩니다. E. coli에서 발현되었으며 분자량은 약 46.7 kDa입니다. 순도는 80% 이상이며, furin 및 단백질 처리 관련 세포·생화학 실험에 적합합니다. 냉장(4°C) 보관, 동결 금지.
- 카탈로그번호
- RP070
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human alpha-1 PDX Recombinant Protein
Thermo Fisher Scientific Human alpha-1 PDX Recombinant Protein
Applications and Test Information
| Application Type | Tested Dilution / Condition | Publications |
|---|---|---|
| Neutralization (Neu) | - | View 1 publication |
| Control (Ctrl) | Assay-dependent | - |
| Inhibition Assays (IA) | Cell studies, 8.0–20 µM | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species | Human |
| Published Species | Human |
| Expression System | E. coli |
| Molecular Weight | 46.7 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >80% |
| Activity | For furin inhibition assays, treat cells with 8.0–20 µM human alpha-1 PDX recombinant protein for 1 hour. For in vitro assays, use 0.1–2.0 µM. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 2.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
Product Specific Information
RP-070 was obtained from E. coli transformed with the alpha1-PDX gene.
It can be used in furin inhibition assays. For furin inhibition assays, cells should be treated with 8.0–20 µM alpha1-PDX for 1 hour. For in vitro assays, 0.1–2.0 µM alpha1-PDX should be used.
Purity: >80% (most lots are 80–95%)
Notes:
- Freezing may damage the protein.
- Once rehydrated, retains optimal reactivity for 2–4 days at 4°C.
- Longer storage possible in serum-rich medium.
- Suitable for biochemical, intracellular trafficking, and protein kinetic assays.
- Molecular weight: approximately 46.7 kDa.
Target Information
Alpha1-PDX is a potent and selective inhibitor of furin (Ki = 0.6 nM).
It was engineered as a variant of alpha1-antitrypsin containing a minimal furin consensus sequence (RXXR).
Cellular expression of alpha1-PDX effectively blocks furin-dependent processing of protein precursors.
Extracellular application also inhibits processing of furin substrates.
Alpha1-PDX has been shown to inhibit processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.