Thermo Fisher Scientific Latrophilin-1 (LPHN1) (extracellular) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitution: Add 50 µL or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Adgrl1 (Latrophilin-1) is a calcium-independent receptor with high affinity for alpha-latrotoxin, a neurotoxin from black widow spider venom that induces exocytosis in neurons and neuroendocrine cells.
It acts as a receptor for TENM2, mediating synaptic cell-cell contact and postsynaptic specialization, possibly regulating exocytosis.
The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR), functioning in both cell adhesion and signal transduction.
Proteolytic cleavage within the cysteine-rich GPS domain yields two non-covalently associated subunits at the cell membrane.
Adgrl1 recruits alpha-latrotoxin to the synaptic plasma membrane.
Alternative splicing produces multiple isoforms.
Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration (Late-Onset, Autosomal Dominant).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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