Thermo Fisher Scientific SPHK2 Polyclonal Antibody
Thermo Fisher Scientific의 SPHK2 Polyclonal Antibody는 인간 SPHK2 단백질을 인식하는 토끼 유래 IgG 항체로, WB 및 IHC(P) 실험에 적합합니다. KLH 결합 합성 펩타이드(1-30 aa)를 면역원으로 사용하며, 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1–30 amino acids from the N-terminal region of human SPHK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2195970 |
Target Information
SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P).
S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer.
SPHK2 is an important signaling molecule with intra- and extracellular functions and has been implicated in regulating:
- Cell differentiation
- Calcium mobilization from intracellular stores
- Apoptosis
The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
These receptors couple to multiple G proteins (e.g., S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a wide range of cellular events including:
- Cell motility
- Survival
- Apoptosis
- Migration
- Cell-cell interaction
S1P also plays roles in:
- Cardiogenesis
- Vascular maturation
- Oocyte survival
- Immune cell trafficking
- Neuronal system and bone cell regulation
S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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