ELK Biotechnology TNAP rabbit pAb
Human ALPL 유래 펩타이드로 제작된 TNAP rabbit polyclonal antibody. WB 및 ELISA에 적합하며, 70kD 밴드 검출. 세포막 및 미토콘드리아 막에 위치하며, 골 형성 및 저인산증 연구에 활용 가능.
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제품명
TNAP rabbit pAb
공급업체
ELK Biotechnology
제품 개요
TNAP rabbit pAb는 인간 ALPL 유래 합성 펩타이드(AA 201–250)를 면역원으로 제작된 rabbit polyclonal antibody입니다. 조직 비특이적 알칼리성 포스파타제(TNAP)를 검출하는 데 사용되며, WB 및 ELISA 분석에 적합합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | ALPL; Alkaline phosphatase; tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ALPL (AA 201–250) |
| Host Species | Rabbit |
| Storage Conditions | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kD |
| GeneID (Human) | 249 |
| Human Swiss-Prot No | P05186 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane; Lipid-anchor, GPI-anchor
Extracellular vesicle membrane; Lipid-anchor, GPI-anchor
Mitochondrion membrane; Lipid-anchor, GPI-anchor
Mitochondrion intermembrane space
Localizes to matrix vesicles (MVs) released by osteogenic cells and to mitochondria of thermogenic fat cells via GPI-anchor.
Background
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).
The first three are located together on chromosome 2, while the tissue non-specific form is on chromosome 1.
The product is a membrane-bound glycosylated enzyme not expressed in any specific tissue, referred to as the tissue-nonspecific form.
Alternative splicing produces multiple transcript variants, including one encoding a preproprotein processed into the mature enzyme.
This enzyme may play a role in bone mineralization. Mutations in this gene are associated with hypophosphatasia, characterized by hypercalcemia and skeletal defects.
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