ELK Biotechnology TNAP rabbit pAb

제품명

TNAP rabbit pAb

공급업체

ELK Biotechnology

제품 개요

TNAP rabbit pAb는 인간 ALPL 유래 합성 펩타이드(AA 201–250)를 면역원으로 제작된 rabbit polyclonal antibody입니다. 조직 비특이적 알칼리성 포스파타제(TNAP)를 검출하는 데 사용되며, WB 및 ELISA 분석에 적합합니다.

제품 스펙

세포 내 위치

Cell membrane; Lipid-anchor, GPI-anchor
Extracellular vesicle membrane; Lipid-anchor, GPI-anchor
Mitochondrion membrane; Lipid-anchor, GPI-anchor
Mitochondrion intermembrane space
Localizes to matrix vesicles (MVs) released by osteogenic cells and to mitochondria of thermogenic fat cells via GPI-anchor.

Background

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).
The first three are located together on chromosome 2, while the tissue non-specific form is on chromosome 1.
The product is a membrane-bound glycosylated enzyme not expressed in any specific tissue, referred to as the tissue-nonspecific form.
Alternative splicing produces multiple transcript variants, including one encoding a preproprotein processed into the mature enzyme.
This enzyme may play a role in bone mineralization. Mutations in this gene are associated with hypophosphatasia, characterized by hypercalcemia and skeletal defects.