ELK Biotechnology 5-LO (phospho Ser523) rabbit pAb

제품명

5-LO (phospho Ser523) rabbit pAb

대체명 (Alternative Names)

ALOX5; LOG5; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase

적용 분야 (Applications)

• Western Blot (WB)
• ELISA

권장 희석 배수 (Recommended Dilutions)

• Western Blot: 1/500 – 1/2000
• ELISA: 1/10000
• Other applications: Not yet tested

면역원 (Immunogen)

Synthesized phospho-peptide around the phosphorylation site of human 5-LO (phospho Ser523)

보관 및 안정성 (Storage)

• Host: Rabbit
• Storage condition: -20°C / 1 year

항체 특성 (Antibody Characteristics)

세포 내 위치 (Cellular Localization)

Cytoplasm, nucleus matrix, nucleus membrane, peripheral membrane protein, cytoplasm perinuclear region, cytoplasm cytosol, nucleus envelope, nucleus intermembrane space.
Shuttles between cytoplasm and nucleus (PubMed:19233132). Found exclusively in the nucleus when phosphorylated on Ser-272 (PubMed:18978352).
Calcium binding promotes translocation from cytosol and nuclear matrix to nuclear envelope and membrane association (PubMed:19233132, PubMed:3118366, PubMed:8245774, PubMed:16275640).

배경 정보 (Background)

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to leukotriene A4.
Leukotrienes are important mediators of inflammatory and allergic conditions. Mutations in the promoter region of this gene can lead to diminished response to antileukotriene drugs used in asthma treatment and may be associated with atherosclerosis and several cancers.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [Provided by RefSeq, Jan 2012]