ELK Biotechnology ALK rabbit pAb
ALK rabbit pAb는 인간, 랫트, 마우스에서 반응하는 폴리클로날 항체로, WB, IHC, IF, ELISA 등 다양한 응용에 적합합니다. 인간 ALK 유래 펩타이드로 면역화되어 신경 발달 및 종양 관련 연구에 활용됩니다. -20°C에서 1년 보관 가능하며, 고품질 IgG 형태입니다.
- 판매단위
- pk
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제품명
ALK rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD antigen CD246 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ALK (AA range: 1570–1619) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150–240 kD |
| GeneID (Human) | 238 |
| Human Swiss-Prot No | Q9UM73 |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
세포 내 위치
Cell membrane; Single-pass type I membrane protein.
Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
배경 정보
This gene encodes a receptor tyrosine kinase, belonging to the insulin receptor superfamily.
It consists of:
- Extracellular domain
- Single-pass transmembrane region
- Intracellular kinase domain
ALK plays a key role in brain development and acts on specific neurons in the nervous system.
It has been found to be rearranged, mutated, or amplified in several tumors, including:
- Anaplastic large cell lymphomas
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements commonly occur in this gene, leading to multiple fusion genes in tumorigenesis, such as:
- ALK (chromosome 2)/EML4 (chromosome 2)
- ALK/RANBP2 (chromosome 2)
- ALK/ATIC (chromosome 2)
- ALK/TFG (chromosome 3)
- ALK/NPM1 (chromosome 5)
- ALK/SQSTM1 (chromosome …)
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