ELK Biotechnology c-Fos (phospho Ser374) rabbit pAb
인간 Fos 단백질의 Ser374 인산화 부위를 인식하는 rabbit polyclonal antibody. IHC, IF, WB, ELISA 등 다양한 응용에 적합. 세포 성장 및 분화 연구에 활용 가능. 핵, ER, 세포질 등 다양한 세포소기관에서 발현 분석에 유용.
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제품명
c-Fos (phospho Ser374) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FOS; G0S7; Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7 |
| Applications | IHC; IF; WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Fos around the phosphorylation site of Ser374 (AA range: 331–380) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 2353 |
| Human Swiss-Prot No | P01100 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Nucleus, Endoplasmic reticulum, Cytoplasm, cytosol.
In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and later to the nucleus.
Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Background
The Fos gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2.
These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, forming the transcription factor complex AP-1.
FOS proteins regulate cell proliferation, differentiation, and transformation. In some cases, FOS gene expression has been associated with apoptotic cell death.
[provided by RefSeq, Jul 2008]
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