ELK Biotechnology HP1α (phospho Ser92) rabbit pAb

제품명

HP1α (phospho Ser92) rabbit pAb

대체 명칭

CBX5, HP1A, Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha

적용 분야 (Applications)

• Immunohistochemistry (IHC)
• Immunofluorescence (IF)
• ELISA

권장 희석 배수 (Recommended Dilutions)

• IHC: 1/100 - 1/300
• ELISA: 1/40000
• 기타 응용 분야는 아직 시험되지 않음

면역원 (Immunogen)

The antiserum was produced against synthesized peptide derived from human HP1 alpha around the phosphorylation site of Ser92.
Amino acid range: 58–107

제품 사양

세포 내 위치 (Cellular Localization)

Nucleus, Chromosome, Chromosome (centromere).
Colocalizes with HNRNPU in the nucleus (PubMed:19617346).
Component of centromeric and pericentromeric heterochromatin.
Associates with chromosomes during mitosis, specifically with chromatin during metaphase and anaphase.

배경 정보 (Background)

This gene encodes a highly conserved nonhistone protein, a member of the heterochromatin protein family. The protein is enriched in heterochromatin and associated with centromeres. It has an N-terminal chromodomain that binds to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) responsible for homodimerization and interaction with chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene on chromosome 3, and multiple alternatively spliced variants encoding the same protein have been identified. [RefSeq, Jul 2008]