ELK Biotechnology SIRT1 (phospho Ser47) rabbit pAb

제품명

SIRT1 (phospho Ser47) rabbit pAb

대체 명칭

SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2

적용 분야

WB, ELISA, IHC

권장 희석 배수

• WB: 1:500–2000
• IHC-p: 1:50–300
• ELISA: 1:2000–20000

면역원

Synthesized phospho-peptide around the phosphorylation site of human SIRT1 (phospho Ser47)

보관 및 안정성

• 종: Rabbit
• 보관 조건: −20°C, 1년 안정

항체 특성

세포 내 위치

Nucleus, PML body, Cytoplasm.
Recruited to nuclear bodies via interaction with PML (PubMed:12006491).
Colocalized with APEX1 in the nucleus (PubMed:19934257).
Found in nucleolus, nuclear euchromatin, heterochromatin, inner membrane (PubMed:15469825).
Shuttles between nucleus and cytoplasm (By similarity).
Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178).
SirtT1 75 kDa fragment: Cytoplasm, Mitochondrion.

배경 정보

This gene encodes a member of the sirtuin family of proteins, homologous to the yeast Sir2 protein.
Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes.
Human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
The protein encoded by this gene belongs to class I of the sirtuin family.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Dec 2008]