ELK Biotechnology Cerebral 1 rabbit pAb
Cerebral 1 rabbit pAb는 인간, 랫드, 마우스 시료에 반응하는 폴리클로날 항체로 WB, IHC, IF, ELISA에 적합합니다. HUCE1 유래 펩타이드로부터 제조되었으며, 핵 및 인 핵소체에 위치한 단백질을 인식합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Cerebral 1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HUCE1 (AA range: 271-320) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 51 kD |
| Gene ID (Human) | 23378 |
| Human Swiss-Prot No | O43159 |
| Cellular Localization | Nucleus, nucleolus. Localizes at rDNA locus. |
| Species Reactivity | Human; Rat; Mouse |
Background
RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast)) is a protein-coding gene. Diseases associated with RRP8 include Bowen-Conradi syndrome and lymphatic system cancer. Related pathways include Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
GO annotations related to this gene include poly(A) RNA binding and methylated histone binding. RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to intracellular energy status by recruiting histone-modifying enzymes.
The eNoSC complex senses cellular energy status: upon glucose starvation, an increase in NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation at H3K9 (H3K9me2) by SUV39H1 and formation of silent chromatin at the rDNA locus. In this complex, RRP8 binds to H3K9me2 and likely acts as a methyltransferase, though its substrates remain unknown.
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