ELK Biotechnology Flt3 rabbit pAb
Flt3 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 세포막 단백질 분석에 유용합니다. 합성 펩타이드 면역원으로 제작되었으며 -20°C에서 1년 보관 가능합니다.
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제품명
Flt3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Flt3 rabbit pAb |
| Alternative Names | FLT3; CD135; FLK2; STK1; Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD antigen CD135 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FLT3. AA range: 565–614 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 117 kD |
| Gene ID (Human) | 2322 |
| Human Swiss-Prot No | P36888 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
[provided by RefSeq, Jan 2015]
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