ELK Biotechnology NDR2 rabbit pAb
NDR2 단백질에 특이적인 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA 등 다양한 실험에 사용 가능. 세포질 및 세포골격 관련 단백질 검출에 적합하며, 고순도 IgG 형태로 제공. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology NDR2 rabbit pAb
제품명
NDR2 rabbit pAb
제품 개요
ELK Biotechnology의 NDR2 rabbit polyclonal antibody는 NDR2 단백질(STK38L)을 인식하는 항체로, 세포 내 신호전달 및 세포골격 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | NDR2 rabbit pAb |
| Alternative Names | STK38L; KIAA0965; NDR2; Serine/threonine-protein kinase 38-like; NDR2 protein kinase; Nuclear Dbf2-related kinase 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000, IHC-p: 1/50–1/300, ELISA: 1/20000. Other applications not yet tested. |
| Immunogen | Synthesized peptide derived from NDR2 (AA range: 380–460) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 54 kD |
| Gene ID (Human) | 23012 |
| Human Swiss-Prot No. | Q9Y2H1 |
| Cellular Localization | Cytoplasm; Cytoplasm, cytoskeleton; Membrane. Associated with actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane. |
| Species Reactivity | Human; Mouse; Rat |
Background
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Enzyme regulation: Activated by binding of S100B, which releases autoinhibitory N-lobe interactions, enabling ATP binding and autophosphorylation of Ser-282. Thr-442 undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote structural changes completing kinase activation.
Autoinhibition is also released by binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.
Function: Involved in regulation of structural processes in differentiating and mature neuronal cells.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity: Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain and 1 protein kinase domain.
Subcellular location: Associated with the actin cytoskeleton.
Subunit: Homodimeric S100B binds two molecules of STK38L (by similarity). Interacts with MOB1 and MOB2.
Tissue specificity: Ubiquitously expressed, with highest levels in thymus.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.