ELK Biotechnology CYP2C8 rabbit pAb
CYP2C8 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 인간 CYP2C8 유래 펩타이드로 면역화되어 약물 대사 관련 연구에 적합. -20°C에서 1년 보관 가능하며, IgG 아이소타입으로 고품질 실험 재현성 제공.
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제품명
CYP2C8 rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CYP2C8; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | IHC-p: 1/100 - 1/300 IF: 1/50 - 1/200 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CYP2C8 (AA range: 241–290) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 1558 |
| Human Swiss-Prot No | P10632 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme metabolizes various xenobiotics, including mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and taxol.
The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding different isoforms have been identified.
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