ELK Biotechnology Intestinal Cell Kinase rabbit pAb
Intestinal Cell Kinase(ICK)에 특이적인 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 인체 유래 합성 펩타이드(AA125-174)로 면역화. 세포 내 핵, 세포질, 섬모 등에서 발현 확인. -20°C 보관으로 1년 안정.
- 판매단위
- pk
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Intestinal Cell Kinase rabbit pAb
제품 개요
ELK Biotechnology의 Intestinal Cell Kinase rabbit polyclonal antibody는 인간 ICK 단백질을 인식하며, 세포 내 다양한 부위(핵, 세포질, 섬모 등)에 존재하는 단백질의 검출에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Intestinal Cell Kinase rabbit pAb |
| Alternative Names | ICK; KIAA0936; Serine/threonine-protein kinase ICK; Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human ICK (AA range: 125–174) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kDa |
| Gene ID (Human) | 22858 |
| Human Swiss-Prot No. | Q9UPZ9 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
- Nucleus
- Cytoplasm, cytosol
- Cell projection, cilium
- Cytoplasm, cytoskeleton, cilium basal body
- Also found at the ciliary tip (PubMed:24797473)
- Nuclear localization observed with GFP-tagged construct in HeLa cells (PubMed:12103360, 19185282)
- Isoform 2: Predominantly cytoplasmic localization observed with N-terminally GFP-tagged construct
Background
Eukaryotic protein kinases are enzymes belonging to a large family sharing a conserved catalytic core common to both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus, producing two variants encoding the same isoform. (RefSeq, Jul 2008)
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