ELK Biotechnology c-Fgr rabbit pAb

ELK Biotechnology c-Fgr rabbit pAb

제품 개요

c-Fgr rabbit pAb는 Src 계열 단백질 티로신 키나아제(FGR)를 인식하는 다클론 항체입니다. 세포막 및 세포골격, 미토콘드리아 내막 등 다양한 세포 위치에서 검출되며, 세포 이동 및 부착 조절 연구에 활용됩니다.

제품 정보

세포 내 위치

Cell membrane; Lipid-anchor; Cytoplasmic side; Cell projection (ruffle membrane); Cytoplasm (cytosol, cytoskeleton); Mitochondrion inner membrane; Mitochondrion intermembrane space.
Detected in mitochondrial intermembrane space and inner membranes (By similarity).
Colocalizes with actin fibers at membrane ruffles and detected at plasma membrane lipid rafts.

Background

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs.
The protein localizes to plasma membrane ruffles and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway.
Infection with Epstein-Barr virus results in overexpression of this gene. Multiple alternatively spliced variants encoding the same protein have been identified. (RefSeq, Jul 2008)