ELK Biotechnology Flg/Bek (phospho Tyr463/466) rabbit pAb

제품명

Flg/Bek (phospho Tyr463/466) rabbit pAb

주요 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein.
Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.
After ligand binding, both receptor and ligand are rapidly internalized.
Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.

배경 (Background)

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution.
FGFR family members differ from one another in their ligand affinities and tissue distribution.
A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain.
The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.
Mutations in this gene have been associated with Pfeiffer syndrome and Jackson-Weiss syndrome.