ELK Biotechnology ABCD1 rabbit pAb
ABCD1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간 ABCD1 유래 펩타이드로 면역화됨. 퍼옥시좀 막 단백질 연구에 적합하며, -20°C에서 1년 보관 가능.
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제품명
ABCD1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ABCD1; ALD; ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein; ALDP |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ABCD1 (AA range: 531–580) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 75 kD |
| Gene ID (Human) | 215 |
| Human Swiss-Prot No. | P33897 |
| Cellular Localization | Peroxisome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters that require a partner half transporter molecule to form a functional homo- or heterodimeric transporter.
This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder.
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