ELK Biotechnology ERα (phospho Ser167) rabbit pAb
인간 ERα의 Ser167 인산화 부위를 인식하는 토끼 다클론 항체. WB, IHC, IF, ELISA에 사용 가능. 핵, 세포질, 세포막에 발현되는 에스트로겐 수용체 검출에 적합. -20℃에서 1년 보관 가능.
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제품명
ERα (phospho Ser167) rabbit pAb
제품 개요
이 항체는 인간 에스트로겐 수용체 알파(Estrogen Receptor α, ERα)의 Ser167 인산화 부위를 인식하도록 제작된 토끼 다클론 항체입니다. 에스트로겐 수용체는 호르몬 결합, DNA 결합, 전사 활성화에 관여하는 핵 수용체로, 생식 및 발달뿐 아니라 다양한 병리적 과정(예: 유방암, 자궁내막암, 골다공증 등)과 관련이 있습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | ERα (phospho Ser167) rabbit pAb |
| Alternative Names | ESR1; ESR; NR3A1; Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Estrogen Receptor-alpha around the phosphorylation site of Ser167 (AA range: 136–185) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 2099 |
| Human Swiss-Prot No. | P03372 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Isoform 1: Nucleus, Cytoplasm, Cell membrane (Peripheral membrane protein, Cytoplasmic side). Minor fraction associated with inner membrane. Isoform 3: Nucleus, Cytoplasm, Cell membrane (Single-pass type I membrane protein; palmitoylated). Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus. Associated with plasma membrane when palmitoylated. |
Background
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and transcriptional activation. The protein localizes mainly to the nucleus and can form homodimers or heterodimers with estrogen receptor 2. Estrogen receptors are essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and splicing result in multiple transcript variants, though many full-length forms remain uncharacterized. (RefSeq, Mar 2014)
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