ELK Biotechnology ERα (phospho Ser106) rabbit pAb
에스트로겐 수용체 ERα의 Ser106 인산화를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 핵 및 세포막 위치 단백질 검출에 적합. -20°C에서 1년 보관 가능.
- 판매단위
- pk
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제품명
ERα (phospho Ser106) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ESR1; ESR; NR3A1; Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Estrogen Receptor-alpha around the phosphorylation site of Ser106 (AA range: 71–120) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 2099 |
| Human Swiss-Prot No. | P03372 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Nucleus, Cytoplasm, Cell membrane (Peripheral membrane protein, Cytoplasmic side). Minor fraction associated with inner membrane. Isoform 3: Nucleus, Cytoplasm, Cell membrane (Peripheral membrane protein, Cytoplasmic side). Single-pass type I membrane protein, associated with inner membrane via palmitoylation (Probable). Subset exists as transmembrane protein with N-terminal extracellular domain. Colocalizes with ZDHHC7 and ZDHHC21 in Golgi apparatus where palmitoylation likely occurs. Associated with plasma membrane when palmitoylated. |
Background
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play roles in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in multiple transcript variants, though the full-length nature of many variants has not been determined. (RefSeq, Mar 2014)
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